Understanding the structural mechanisms of protein–ligand binding and their dependence on protein sequence and conformation is of fundamental importance for biomedical research. Here we investigate ...

Domestic researchers have captured the 'hidden stage' of how cell membrane proteins pair for the first time in the world. This discovery breaks the existing theory that proteins bind all at once, ...

Isothermal titration calorimetry (ITC) is an analytical technique, which is often thought of as the gold standard for analyzing intermolecular interactions. It is a titrimetric method, which is a ...