Atrophy of skeletal muscle in cancer cachexia results in weakness (asthenia) and death. Muscle mass is controlled by the rate of protein synthesis and the rate of protein degradation, which in the ...

Anti-cachectic effects of a novel peptide nucleic acid: Preliminary results of a phase 1/11 clinical trial Authors: J. T. D'Olimpio, S. Z. Hirschman, Z. Shtemer, and M. Didiego Authors Info & ...

Tumor growth is associated with profound metabolic and neurochemical alterations, which can lead to the onset of anorexia−cachexia syndrome. Anorexia is defined as the loss of the desire to eat, while ...

A recent Nature Metabolism study reports that circulating lactate levels are positively associated with weight loss in cancer cachexia patients. Mouse model experiments also revealed that ...