One of the biggest quests in biology is understanding how every cell in an animal's body carries an identical genome yet still gives rise to a kaleidoscope of different cell types and tissues. A ...

“Expression tells us what cells do, but regulatory DNA tells us where they come from, how they develop, and which germ layer ...

Purkinje cells were discovered by Jan Evangelista Purkyně in 1839 and famously illustrated by Santiago Ramón y Cajal in 1899. This Ramón y Cajal drawing shows cerebellar Purkinje cells (A) and granule ...

That’s the conclusion of a new study in Nature, which pitted synthetic bacterial cells against the force of evolution. Stripped down to a skeletal genetic blueprint, the artificial cells started with ...

In a study published in Developmental Cell, a team led by Prof. Robert K. Naumann from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences (CAS), and researchers from BGI ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

A recent review by Carlo Maley, a researcher at Arizona State University, and Lucie Laplane from the University of Paris Pantheon-Sorbonne critiques the dominant theory of cancer evolution. The ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...