Using an approach similar to classical yeast genetics, the authors use somatic cell genetics in human cells to replace the endogenous CENP-A with H3–CENP-A chimaeras for complementation testing. They ...

Figure 1: Analyses of hybrids by their mtDNA genotypes and phenotypic expression of mitochondrial respiratory function. Figure 2: COX activity of individual mitochondria in single hybrids. We ...