本文聚焦于构建人工生命系统的核心挑战——如何实现遗传信息流的自我维持。研究人员开发了名为LoopReX的体外无细胞系统，利用大肠杆菌粗提物成功重构了转录-翻译偶联的DNA复制（TTcDR）过程。该系统通过phi29DNAP和T7RNAP的最小化机器、机器学习优化配方以及 ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA—its genome—and segregate it equally ...