In a transformative new paper, Alex Gillespie and Brady Wagoner extend the concept of “looping effects,” originally introduced by philosopher Ian Hacking to describe the two-way relationship between ...

Loop diuretics are widely used, especially in patients with hypertension or heart failure plus renal dysfunction. Such patients are particularly susceptible to untoward drug effects. It is, therefore, ...

Discriminating the gene target of a distal regulatory element from other nearby transcribed genes is a challenging problem with the potential to illuminate the causal underpinnings of complex diseases ...