A recent review by Carlo Maley, a researcher at Arizona State University, and Lucie Laplane from the University of Paris Pantheon-Sorbonne critiques the dominant theory of cancer evolution. The ...

Characterizing clonal evolution in blood cancers like acute myeloid leukemia (AML) is critical for understanding their mutational histories and how cell populations change during disease development.

Several specific genetic mutations have been associated with colorectal cancer (CRC) and dysplasia in patients with ulcerative colitis (UC). [1] Many of these genetic alterations are unique to ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

This is a preview. Log in through your library . Abstract The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms ...

Mudras in Medicine: A Role for Dance in Appreciating Nonverbal Communication in the Clinical Encounter The risk of sMN in AA is associated with disease severity, lack of response to treatment, and ...

Researchers published a new study, “Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution,” in Cell that they say solves the mystery of what drives the genomic ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

A new proof-of-concept method reliably engineered a hotspot mutation of SF3B1, a gene-splicing gene, into diverse cancer cell lines, outperforming other contemporary editing approaches. Oncogenesis ...